Question : My husband has poor sperm DNA fragmentation. What techniques do you advise to increase our pregnancy rate?
Answer : The case of infertility problems caused by poor DNA fragmentation can be initially solved by figuring out the reasons behind it and fix such causes accordingly, such as smoking, infection in the reproductive system, certain medical prescription, exposure to high temperature or dangerous chemicals, etc. For IVF treatment, it is recommended that you opt for the Magnetic Activated Cell Sorting (MACS) that can separate healthy sperms from those with fragmented DNA strands. You can also choose to use the Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) that carefully selects good sperms in the semen through microscope. This technique allows the operator to observe better details of sperms compared to the conventional Intracytoplasmic Sperm Injection (ICSI), thus better success rate.
Question : Embryo transfer done with hormoneinduced endometrial receptivity or with natural ovulation has a better chance of success?
Answer : A comparative study to examine the results of embryo transfer performed on hormone-inducing endometrial receptivity and natural ovulation suggests that the success rates of the two techniques are no different. Patients can use either technique deemed most appropriate for their condition as both have pros and cons. Hormone-taking method allows for more flexibility in appointing a doctor and scheduling the date for embryo transfer, while natural ovulation is more suitable for those who need to avoid hormone pills, as well as saving cost.
Obstetrician and Gynecologist, Reproductive Medicine
JETANIN Journal Vol.11 No.2