How does PGT-A increase the success rate of pregnancy?
In an embryo, each cell contains 23 pairs of chromosomes (46 total chromosomes). In case an embryo has extra or missing chromosome even partially (aneuploidy) is unlikely to implant in the uterus. If it implants, there is a chance of miscarriage or having a baby with genetic disorder such as Down syndrome. Down syndrome is the most common known cases of genetic disorder. It is caused by an extra copy of chromosome 21 (Trisomy 21). Woman has a chance to have a baby with Down syndrome or another chromosome abnormality if she is older than 35. Most children with Down syndrome have physical and intellectual disabilities. Thus, using PGT-A in the IVF treatment has been a practical option to avoid the birth of affected children. PGT-A can improve IVF success rates, especially in infertile patients and patients with a history of failed treatments such as women over the age of 35 (advanced maternal age) which is chromosome aneuploidy rate in eggs increases after the age of 35, patients with prior recurrent implantation failures, patients with prior recurrent miscarriages and prior child with a genetic disorder.
PGT-A with NGS technology
Next Generation Sequencing (NGS) is the most commonly used technology for PGT-A. NGS is the rapid technique that requires only one or a few cells of each embryo for comprehensive chromosome screening. It also has a high resolution which can detect partial chromosome (deletions/ duplications) aneuploidy with a high level of accuracy (99.9%).3 In addition, NGS can detect mosaicism which occurs when two or more embryonic cells with different chromosome number are present within the same embryo. Mosaicism is caused by an error in cell division. It may result in miscarriage or baby born with health issues. Approximately 1% of Down syndrome children are mosaics. 5 The severity of mosaic Down syndrome symptoms is depend on the percentage of abnormal cells. At Jetanin, we perform PGT-A using the latest NGS automation system that is a standard technology and widely used in nowadays. Thus, you will get a fast, accurate and effective testing service from our PGT-A.
